That means Windows is blocking the engine from starting or blocking the ports
Try doing a “clean install” using the steps provided here: MCEBuddy - Common Install, Uninstall and Start Up Issues
Then open the Control panel → Click on Services (or access it from the Task Manager if you’re using Windows 8.1 or 10), find the service MCEBuddy2x and click Start.
If the service has started then your firewall or antivirus is blocking the port (23332) used by the MCEBuddy service (engine) to communicate with the client (GUI).