From your logs, the comskip path is invalid so it’s failing when trying to access it
ERROR> 2025-07-28T12:30:10 MCEBuddy.AppWrapper.Comskip → Application File Not Found or not accessible : C:\Program Files\MCEBuddy2x\comskip
Remove your custom comskip path or make it point to the comskip exe file (not folder) in your Settings → System settings page.
Custom Comskip Path → C:\Program Files\MCEBuddy2x\comskip