The donator version that comes with MCEBuddy is quite old (version 0.82.003 from 2017-09-30). The current donator version is 0.82.012 from 2022-02-25. The notable thing the more current Comskip donator version has is a newer embedded FFMPEG v4.3, and supports 4k and 10bit video processing. Donator version is what gets you mpeg4 video processing.
However it doesn’t really need to have all kinds of modern codec support, because most input DVR video formats are MP2 or MP4 anyway and almost all transcoding will start with a conversion to MP2 before MCEBuddy triggers comskip. The hardware CPU/GPU support comes from the embedded FFMPEG baked into comskip.
The summary is yes, it will speed up the ad detection step, but overall, ad detection is only a really small part of the overall transcoding process.
In the end, it’s a personal decision for you. Would you benefit? Sure. Are you missing out or taking a huge performance hit if you don’t? Not really.